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T-

T-Bactum (EB23 18235Y / EB2318235Y)

✓ Approved

Essex Bio-Technology Limited · 治疗药物

什么是 T-Bactum？

T-Bactum 是一种治疗药物，由Essex Bio-Technology Limited研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名EB23 18235Y, EB2318235Y
公司Essex Bio-Technology Limited
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Essex Bio-Technology Limited

治疗适应症

T-Bactum 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsOral infection✓ Approved

相关研究文献

PubMedJournal of the Egyptian National Cancer Institute2026-07-27

The promising role of engineered T lymphocytes in immunotherapy for high-grade serous ovarian carcinoma: a review of mechanisms, clinical landscape, and future strategies.

Faradina Dwi D, Rusda Muhammad M, Siregar Muhammad Fidel Ganis MFG, Adella Cut Adeya CA et al.

High-grade serous ovarian carcinoma (HGSC) demonstrates poor prognosis with approximately 80% recurrence rates and significant chemotherapy resistance. Conventional checkpoint inhibitors show limited efficacy (10-15%), necessitating alternative immunotherapeutic approaches. Engineered T lymphocytes, particularly CAR-T and TCR-T cells, have emerged as promising strategies for HGSC. This literature review examines the promising role of engineered T lymphocytes in immunotherapy for HGSC. A comprehensive literature search was conducted across PubMed, Scopus, and Cochrane Library databases for peer-reviewed studies published between 2015 and 2025. Search terms included "engineered T lymphocytes," "CAR-T cells," "TCR-T cells," "ovarian cancer immunotherapy". CAR-T cells demonstrate promising preclinical antitumor activity in HGSC, with high-avidity T-cell clones showing robust efficacy. Engineered T lymphocytes demonstrate promising approaches across disease contexts. In high-grade serous ovarian carcinoma, Engineered T lymphocytes orchestrate tumor cell apoptosis through coordinated granzyme/perforin and Fas/FasL signaling, enabling rapid cytotoxic elimination of multiple tumor targets.

PMID 42507306
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PubMedImmunology2026-07-27

Methionine Regulates Antitumour Function of CD8+ T Cells Through Polyamine Synthesis.

Zhao Tian T, Carleton Gillian A GA, Preshaw Sam S, MacPherson Sarah S et al.

Methionine is an essential amino acid critical for T cell activation. While methionine restriction (MR) combined with immune checkpoint blockade has been shown to enhance T cell function, the impact of methionine on adoptive T cell therapies remains unknown. Here, we examined the functionality of T cells under MR and pharmaceutical inhibition of the methionine cycle (MAT2Ai), using primary T cells and a murine adoptive T cell therapy model. In vitro, transient MR or MAT2Ai treatment increased interferon gamma (IFNγ) expression in CD8+ T cells, whereas sustained MR led to the upregulation of T cell exhaustion-associated markers. Mechanistically, transient MR suppressed the polyamine synthesis pathway, and supplementation with polyamines reversed MR-induced IFNγ expression. Genetic ablation of S-adenosylmethionine decarboxylase, an enzyme involved in the polyamine synthesis pathway, recapitulated the effect of MR, indicating that transient MR enhances T cell function by inhibiting polyamine synthesis. Despite this, transient MR treatment of ovalbumin (OVA)-specific (OT-I) CD8+ T cells prior to adoptive transfer did not improve antitumour efficacy against EG7-OVA tumours in vivo. In contrast, sustained dietary MR accelerated EG7-OVA tumour growth in mice treated with OT-I T cells, demonstrating that methionine availability is essential for the activity of donor T cells. Importantly, sustained dietary MR promoted terminally exhausted phenotype in tumour-infiltrating donor CD8+ T cells, but not in host T cells. These findings suggest that enhancing methionine availability in the tumour microenvironment may improve the efficacy of adoptive T cell therapies.

PMID 42503479
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PubMedVaccines2026-07-27

Potential Roles of Gamma-Delta T Cells in a Bacterial Immun-Ization Model.

Talbot Lee Anne LA, Manjikian Raffi R, Bitsaktsis Constantine C

Background/Objective: Francisella tularensis is a highly infectious intracellular pathogen that causes severe pulmonary tularemia following aerosol exposure, yet no licensed vaccine exists. Because infection initiates at the respiratory mucosa, understanding mechanisms of protective pulmonary immunity is critical for mucosal vaccine development. This study investigated the role of lung-resident γδ T cells following intranasal immunization with inactivated F. tularensis (iFt) and subsequent lethal challenge with live vaccine strain (LVS). Methods: Mice were intranasally immunized with iFt and later challenged with lethal LVS. Pulmonary immune responses were evaluated using flow cytometry and cytokine analysis. Recruitment of γδ and αβ T cells, production of IL-17 and IFN-γ, neutrophil infiltration, and γδ T cell memory phenotypes were assessed in naïve and immunized mice following infection. Results: Primary LVS infection induced rapid recruitment of γδ T cells to the lung beginning on Day 2 post-infection, preceding significant αβ T cell accumulation. Increased pulmonary IL-17 and IFN-γ correlated with expansion of IL-17- and IFN-γ-associated γδ T cell populations. Following iFt immunization, mice demonstrated enhanced survival after lethal LVS challenge, accompanied by early increases in pulmonary IL-17 and IL-17 producing γδ T cells. Immunized mice also exhibited expansion of effector memory and central memory γδ T cell populations associated with IL-17 production. Conclusions: These findings identify IL-17 producing γδ T cells as contributors to early mucosal immunity following intranasal vaccination against F. tularensis and suggest that targeting lung-resident γδ T cells may support the development of next-generation mucosal vaccines against respiratory pathogens.

PMID 42506627
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PubMedOncoimmunology2026-07-27

Characterization of persistent HPV-specific activated T cells in head and neck squamous cell carcinoma.

Ishihara Hiromasa H, Shibata Hirofumi H, Muraoka Daisuke D, Demachi-Okamura Ayako A et al.

Human papillomavirus-positive oropharyngeal squamous cell carcinoma (HPV + OPSCC) generally has favorable outcomes yet remains prone to late recurrence. Durable control likely depends on persistent tumor-specific CD8+ T cells, but their persistence and function in metastasis are poorly understood. We integrated bulk RNA sequencing (n = 56) with single-cell RNA and paired T-cell receptor (TCR) sequencing of tumor-infiltrating CD8+ T cells (n = 4), including a longitudinal primary-lung metastasis pair obtained three years after curative therapy. HPV genotyping, HLA typing, epitope prediction, and NFAT-reporter Jurkat-luciferase assays were used to identify and functionally validate HPV16 E6/E7-specific TCRs. Repertoire tracking and single-cell/bulk transcriptomics were evaluated. HPV + tumors showed higher inferred CD8+ T cell infiltration and more favorable prognosis than HPV- tumors. Single-cell analysis revealed oligoclonally expanded exhausted clusters enriched in HPV tumor-specific CD8+ T cells. We isolated and functionally validated nine patient-derived HPV16 E6/E7-specific TCRs. High-avidity receptors recognizing an alternatively spliced region in E6 (aa 49-110; E6*) persisted in metastatic lesions, whereas lower-avidity clones, including an E7_11-19-specific TCR currently under clinical investigation, were lost. Compared with the primary tumor, metastatic lesions showed reduced stem-like/TCF7-associated CD8+ T-cell populations and enrichment of HPV-specific CD8+ T cells expressing KLRB1 and ZNF683, consistent with a tissue-adapted TRM-like transcriptional state with inhibitory signaling features. High-avidity, KLRB1 + HPV-specific CD8+ T cells represent a persistent effector subset with prognostic and therapeutic relevance to HPV + OPSCC. Their persistence in metastatic lesions and association with reduced recurrence risk support further investigation of KLRB1-associated HPV-reactive T-cell states as biomarkers and immunotherapeutic targets.

PMID 42503644
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PubMedMagnetic resonance in medicine2026-07-27

A Flexible Graphite-Silicone Pad for Improved Fat Suppression in Cervical Spine MRI at 5 T via Passive B0 Shimming.

Yang Yihan Y, Liu Ziyu Z, Hong Haotian H, Zhang Weijun W et al.

Susceptibility-induced B 0 inhomogeneity at the posterior neck degrades spectral fat suppression in cervical spine MRI at 5 T and above. We describe a flexible graphite-silicone pad for passive B 0 shimming and assess its effect on field homogeneity and fat-suppressed imaging alongside the scanner's active shim. Pads were fabricated by dispersing high-purity graphite powder in a biocompatible silicone elastomer and casting the mixture in a 3D-printed mold shaped to the posterior neck and head-neck receive coil. Five graphite-to-silicone mass ratios (1.5:100 through 8:100) were screened in one volunteer on a 5 T scanner using dual-echo B 0 mapping and fat-suppressed T 1 - and T 2 -weighted FSE. The selected ratio (4.5:100) was evaluated in five healthy volunteers under volume-based active shimming, with and without the pad in randomized order. In the screening volunteer under Volume shimming, the 4.5:100 pad reduced the posterior-neck field σ from 0.740 to 0.458 ppm, a 38% reduction at matched shim mode. Across the five validation subjects, σ decreased in every case under Volume shimming, from 0.911 ± 0.117 to 0.455 ± 0.054 ppm (individual reductions 41%-55%). Residual hyperintense fat seen with the standard pad was no longer present on sagittal T 1 - or T 2 -weighted images, and the improvement extended to the supraclavicular region on coronal T 1 -weighted images. A flexible graphite-silicone pad complements active shimming and improves spectral fat suppression in cervical spine MRI at 5 T. Evaluation in patients and on EPI-based sequences remains to be done.

PMID 42504035
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PubMedNMR in biomedicine2026-07-27

Quantitative MRI to Assess Portal Pressure in Patients With Liver Disease: Validation at 3 T.

Bradley Christopher R CR, Scott Robert R, Cox Eleanor F EF, Palaniyappan Naaventhan N et al.

Hepatic venous pressure gradient (HVPG) is the gold standard for assessing portal hypertension (PH). We previously demonstrated that a bivariate MRI model combining liver T1 and splenic artery velocity at 1.5 T correlates with HVPG. This study aimed to evaluate this model at 3 T and investigate additional splanchnic MRI measures as potential non-invasive markers of portal pressure. Data from 40 participants (15 metabolic dysfunction-associated steatotic liver disease [MASLD]/13 alcohol-related liver disease [ArLD]/12 other, 55 ± 14 years) scanned at 1.5 T (retrospective) and 42 participants (21 MASLD/14 ArLD/7 other, 60 ± 12 years) scanned prospectively at 3 T who underwent clinical HVPG measurement were analysed. Liver and spleen iron-corrected T1 (cT1) were acquired using fat-suppressed spin-echo echo-planar T1 mapping, and splanchnic haemodynamics were assessed using phase-contrast MRI. Correlations between MRI parameters and HVPG were assessed, and previously derived univariate (liver cT1) and bivariate (liver cT1 + splenic artery velocity) models were evaluated using receiver operating characteristic (ROC) analysis for PH (HVPG ≥ 5 mmHg), clinically significant PH (CSPH; HVPG ≥ 10 mmHg) and increased risk of mortality (HVPG ≥ 15 mmHg). Liver cT1 at 3 T showed a strong positive correlation with HVPG across the full range (0-23 mmHg; R = 0.73, p < 0.0001). After field adjustment, pooled 1.5 and 3 T liver cT1 maintained a strong correlation with HVPG (R = 0.76, p < 0.0001). At 3 T, the univariate liver cT1 model outperformed the bivariate model, achieving AUROCs of 0.74, 0.86 and 0.91 for detecting PH, CSPH and HVPG ≥ 15 mmHg, respectively. In contrast, spleen cT1 and superior mesenteric artery velocity correlated with HVPG only up to ~15 mmHg, after which values plateaued or declined. Liver cT1 MRI at 3 T provides a surrogate of portal pressure across the full HVPG range and outperforms a previously proposed bivariate model. Spleen and splanchnic haemodynamic measures demonstrate a ceiling effect at higher portal pressures > 15 mmHg.

PMID 42503440
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