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phenylpropanolamine (Dristan SR / Histabid / Dexatrim)

✓ Approved

Lumara Health · 小分子 · 小分子

什么是 phenylpropanolamine？

phenylpropanolamine 是一种小分子，由Lumara Health研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Dristan SR, Histabid, Dexatrim
公司Lumara Health
药物类别小分子
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Lumara Health

治疗适应症

phenylpropanolamine 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Respiratory, thoracic and mediastinal disordersCough✓ Approved

相关研究文献

PubMedGels (Basel, Switzerland)2026-07-27

Polydopamine-Modified Boron Nitride Reinforced Silicone Gel Composites with Enhanced Thermal Conductivity and Electrical Insulation Performance.

Feng Mengjia M, Zhao Chaoyue C, Li Wenbo W, Lv Xinfeng X et al.

Silicone gel (SG) is widely used as a soft encapsulation material for high-voltage power devices because of its excellent flexibility, thermal stability, and electrical insulation. However, its intrinsically low thermal conductivity and susceptibility to partial discharge (PD) at triple-junction interfaces restrict long-term operational reliability. In this study, polydopamine-modified hexagonal boron nitride (P-BN) was introduced into silicone gel to construct thermally conductive and electrically insulating composites. The SG/P-BN composites exhibited reduced filler agglomeration and a more continuous filler-matrix morphology than the corresponding SG/BN composites, while the model-extrapolated trap analysis suggested composition-dependent changes in the higher energy charge trapping states of the P-BN-containing composites. As a result, the SG/P-BN composites exhibited enhanced thermal stability, reduced coefficient of thermal expansion, and improved heat-transfer capability, with thermal conductivity increasing from 0.183 W/m·K for pristine SG to 0.25 W/m·K. The composite containing 2 wt% P-BN showed the best insulation performance, with breakdown strength increasing from 24.05 to 28.45 kV/mm at 25 °C and from 19.59 to 24.71 kV/mm at 150 °C. Under a simplified triple-junction laboratory configuration, the PD inception voltage increased from approximately 3.1 kV for pristine SG to 4.1 kV for SG/P-BN2, accompanied by fewer high-amplitude discharges. This work demonstrates improved material-level thermal conductivity and electrical insulation performance of P-BN-containing silicone gel composites under the investigated laboratory conditions.

PMID 42505326
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PubMedGels (Basel, Switzerland)2026-07-27

Pulsed Electric Field-Modified Hot-Pressed Peanut Meal Protein for Gel-like High Internal Phase Emulsions.

Liao Yutong Y, Song Jiayi J, Huang Jiaxin J, Liang Kexin K et al.

Hot-pressed peanut protein isolate (HPPI), severely denatured during oil extraction, exhibits limited interfacial functionality, restricting its application in structured emulsions. In this study, high-voltage pulsed electric field (PEF) was employed to modulate the structural and interfacial properties of HPPI, a sustainable food biopolymer. PEF treatment induced conformational rearrangement, including a shift in secondary structure from α-helix to β-sheet and increased exposure of hydrophobic residues. These structural changes reduced particle size and increased surface charge, with optimal modification at 2.5 kV/cm. Consequently, interfacial activity was significantly improved, as evidenced by decreased interfacial tension and increased dilatational modulus, indicating a more elastic interfacial film was formed. The modified protein (2.5 kV/cm) effectively stabilized high internal phase emulsions (HIPEs) with typical gel-like viscoelastic features, achieving optimal stability at 2.0 wt% protein concentration, 75% oil phase fraction, and NaCl concentrations below 100 mM. Overall, PEF treatment enhances the interfacial functionality of HPPI by modulating its structure and interfacial film properties, thereby facilitating the fabrication of biopolymer-based food-grade HIPEs for practical food applications.

PMID 42505255
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PubMedBiomimetics (Basel, Switzerland)2026-07-27

SE-Attention Augmented Hybrid CNN-BiLSTM Model for Leakage Current-Based Detection of Cracked and Broken High-Voltage Porcelain Insulators.

Alçin Ömer Faruk ÖF, Özküçük Muhammed Buğracan MB, Gençoğlu Muhsin Tunay MT

Extreme and sudden temperature fluctuations observed as a result of global climate change increase the environmental pressure on energy transmission infrastructure. These meteorological changes significantly increase the risk of failure for porcelain insulators, which exhibit low thermal resistance and are susceptible to sudden arcing and surface deformations. In this study, a hybrid CNN-BiLSTM-SE architecture augmented with the Squeeze-and-Excitation attention mechanism is proposed using surface leakage current signals to diagnose healthy, cracked, and broken structural conditions in three-unit porcelain insulators. The SE block in the architecture dynamically rescales feature maps from CNN layers on a channel-by-channel basis. Thus, it highlights the signal characteristic that is dominant for fault diagnosis just before the BiLSTM units learn temporal dependencies. Leakage current data were obtained under an experimental setup at 60 kV for 15 different conditions covering all possible combinations of healthy, cracked, and broken insulator units. The raw signals were preprocessed with the Savitzky-Golay filter to suppress noise while preserving the diagnostic waveform morphology. 24 features covering time-domain statistics, frequency-domain spectral characteristics, and wavelet-domain energy components were extracted and used as model inputs. The CNN-BiLSTM-SE architecture achieved a classification accuracy of 93.83%, surpassing the standalone CNN (88.89%), BiLSTM (87.65%), and CNN-BiLSTM (91.36%) models, as well as classical machine-learning baselines (SVM: 87.65%, Random Forest: 90.12%, Boosted Trees: 87.65%).

PMID 42505490
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PubMedTomography (Ann Arbor, Mich.)2026-07-27

Impact of Different Energy Levels of Virtual Monoenergetic Reconstructions on Radiomic Features Stability in Organic Phantom Imaging Using Photon-Counting CT.

Vahidi Noghani Farroch F, Rotkopf Lukas T LT, Schoenberg Stefan O SO, Froelich Matthias F MF et al.

Objectives: This study investigates the repeatability and reproducibility of radiomic features extracted from different energy levels of virtual monoenergetic reconstruction (VMER) and polyenergetic reconstruction (PER) obtained with photon-counting computed tomography (PCCT). Methods: Sixteen organic phantoms were scanned twice in a test-retest format using a 120 kV tube potential and tube currents of 10, 50, and 100 mAs. After rotating the phantoms 90° around their z-axis, additional test-retest scans were performed. A PER and 16 VMERs were generated. Segmentation and extraction of 105 original radiomic features followed. The repeatability and reproducibility of these features were assessed using the concordance correlation coefficient (CCC) for agreement and the intraclass correlation coefficient (ICC) for reliability, excluding 14 shape-based features from the analysis. Results: On average, 85 out of 91 radiomic features from VMER showed high repeatability. Approximately 30% of features demonstrated high intra-scan and inter-scan reproducibility when comparing PER and VMER. For different energy levels of VMER, around 78% showed high intra-scan reproducibility, and 74% showed high inter-scan reproducibility. Comparing the average values of test and retest scans in both the initial and rotated states revealed that 65% of features showed high agreement and 73% high reliability for PER, while for VMER, these values were 51% and 55%, respectively. Conclusions: Radiomic features from VMERs showed high test-retest repeatability, whereas reproducibility across reconstruction types and widely separated energy levels was more limited. These findings suggest that energy levels should be carefully standardized when radiomic features are extracted from PCCT-derived VMER images.

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PubMedRSC advances2026-07-25

Enhancing broadband electromagnetic wave absorption performance of NZFO/BSTO multiferroic materials in the X and Ku bands.

Tung Do Khanh DK, Son Tung Bui B, Viet Nguyen Van NV, Truong Nguyen Xuan NX et al.

Multiferroic composites with the composition xNi0.5Zn0.5Fe2O4/(1 - x)(Ba0.8Sr0.2TiO3) (denoted as NZFO/BSTO) (where x = 0, 0.1, 0.2, 0.3, 0.4, and 1.0) were fabricated using a solid-state reaction method combined with spark plasma sintering. The obtained materials exhibited an average particle size of approximately 500 nm. X-ray diffraction analysis confirms the co-existence of the ferromagnetic Ni0.5Zn0.5Fe2O4 (NZFO) phase and the ferroelectric Ba0.8Sr0.2TiO3 (BSTO) phase. As the NZFO content increases from x = 0.1 to 0.4, the saturation magnetization (M s) rises from 13.6 to 56.9 emu g-1, while the remanent magnetization (M r) increases from 0.71 to 1.88 emu g-1. Simultaneously, the P-E hysteresis loops become more pronounced, with a significant increase in both the maximum polarization (P m) and remanent polarization (P r). The coercive electric field (E c) also increases markedly from 1.94 kV cm-1 to 3.56 kV cm-1 under an applied electric field of 12.5 kV cm-1. The composite with the ferromagnetic phase fraction x = 0.4 exhibits excellent broadband electromagnetic wave absorption performance. At thicknesses of 2.0 mm and 2.5 mm, the effective absorption bandwidth exceeds 5.4 GHz and 5.7 GHz, respectively. Notably, minimum reflection loss (RLmin) values of -48.3 dB and -43.9 dB are achieved at 15.7 GHz and 12.6 GHz, respectively. These results demonstrate the strong potential of the material for practical applications in electromagnetic wave absorption in the X-band and Ku-band frequency ranges, particularly in radar stealth and military technologies.

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PubMedAdvanced materials (Deerfield Beach, Fla.)2026-07-25

Synergistic Design Strategies Breaking the Energy Storage Trade-Off in Lead-Free Dielectrics.

Jing Ruiyi R, Zhang Leiyang L, Yang Yule Y, Man Wanchang W et al.

Development of lead-free dielectric capacitors with simultaneously high recoverable energy-storage (ES) density (Wrec) and breakdown strength (Eb) is hindered by a fundamental constraint; although high Eb permits large electric fields, conventional ferroelectrics suffer from premature polarization saturation, limiting further enhancement of Wrec. We demonstrate a mechanism-guided strategy for Bi0.5Na0.5TiO3 (BNT)-based relaxor ferroelectric ceramics, centered on optimized polar nanoregion (PNR) responses and delayed polarization saturation. Phase-field simulations show that interconnected rhombohedral/tetragonal (R/T)-related PNRs with appropriate size and dynamic responsiveness can be progressively activated under electric fields, enabling delayed polarization saturation, sustained ΔP growth, and low hysteresis loss. Guided by this mechanism, compositional disorder, R/T phase coexistence are integrated in the BNT-based system to construct an optimized PNR landscape. The optimized multilayer ceramic capacitors deliver a record ES potential (ξ = Wrec/Eb) of 278 J kV-1 m-2, together with a high Wrec of 26.4 J cm-3 at 950 kV cm-1 and 89% ES efficiency. Atomic-resolution microscopy confirms pronounced local chemical heterogeneity and coexisting R/T-related PNRs, consistent with the optimized PNR response predicted by phase-field simulations. These results establish a generalizable framework for overcoming the intrinsic ξ-Eb trade-off and advancing next-generation high-Wrec dielectric capacitors for ES and pulsed-power applications.

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